Dados do Trabalho

Título

Association of SLC11A1, LECT2, CCL1, CCL16, and IL4 polymorphisms with visceral leishmaniasis in HIV-coinfected patients in Pernambuco, Brazil

Introdução

Visceral leishmaniasis-HIV co-infection is a life-threatening neglected disease that has increased worldwide, mainly in Brazil. Nutritional status, age, and host genetic factors are important variables determining susceptibility to development of clinical forms of VL.

Objetivo (s)

The aim of the present study was to analyze the associations of SLC11A1, LECT2, CCL1, CCL16, and IL4 genetic polymorphisms with susceptibility to VL-HIV coinfection in Pernambuco.

Material e Métodos

The study analyzed 309 DNA samples extracted from the peripheral blood of HIV patients, and clinical and hematological data were collected from medical records. The diagnosis of VL was confirmed in 110 out of 309 patients; genotyping was carried out by TaqMan assays afterwards. Differences were considered statistically significant at p < 0.05. The Research Ethics Committee of the Aggeu Magalhães Institute (CAAE no. 61218816.1.0000.5190) approved the study.

Resultados e Conclusão

The results only confirmed the association between the SLC11A1 polymorphism (rs3731865) and VL-HIV coinfection (p = 0.0206, OR 1.8126, 95% CI 1.1050–2.9727). Moreover, the SLC11A1 genotype GG (p = 0.0050, OR 3.0395, 95% CI 1.4065–6.5789) and CD4+ T lymphocyte count (p = 0.0030, OR 0.9980, 95% CI 0.9970–0.9990) were associated with VL-HIV coinfection in a multivariate model. The polymorphism of the SLC11A1 gene (rs3731865) was associated with VL-HIV coinfection, suggesting a possible genetic mechanism involved in the susceptibility to VL in HIV patients. Therefore, our finding can suggest new therapeutic targets and genetic markers for the VL-HIV-coinfected population.

Palavras-chave

HIV; Visceral leishmaniasis; Polymorphisms; Susceptibility

Agradecimentos

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) - Finance Code 001, Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco [FACEPE (APQ 1712-4.01/15)] and Fundação Oswaldo Cruz (Fiocruz) [(PAPES VII—Process (401857/2015-8)].