Dados do Trabalho

Título

HSV-1: The Silent outbreak Plaguing Brazil's Midwest Indig-enous Populations

Introdução

Human alphaherpesvirus 1 (HSV-1) is a viral infection that can be transmitted orally and sexually through mucosal epithelial cells. The virus is also capable of causing much more serious diseases, such as herpetic keratitis, herpes encephalitis, which can be fatal if untreated, and widespread neonatal infections. This phenomenon is called the epidemiological transition, characterized by significant changes in the oc-currence and transmission patterns of infection.

Objetivo (s)

We estimated the exact prevalence of anti-HSV- 1 antibodies and correlated it with the demographic and behavioral aspects of the Indigenous population of the Jaguapirú and Bororó villages (Dourados, Mato Grosso do Sul (MS), Brazil).

Material e Métodos

In total, 1138 individuals (>18 years old) were administered serologic tests and viral load by qPCR UL 39.

Resultados e Conclusão

The prevalence of anti-HSV-1 IgM was 20% and anti-HSV-1 IgG was 97.5%. The prevalence of anti-HSV-1 antibodies was higher in females (97.6%) and males (97.3%). Anti-HSV-1 antibodies were found in 17.1%, 21.2%, 12.5%, and 22% of participants with urinary problems, genital wounds, genital warts, and urethral discharge, respectively. The circulation of virus was confirmed by real-time PCR, HSV-1 DNA was detected in 26% of anti-HSV1 IgM positive samples. Viral loads ranged from 5,99E+02 to 3,36E+13. In summary, the seroprevalence of HSV-1 IgM and the detection of HSV-1 DNA in the Indigenous population confirm a silent outbreak. Furthermore, the prevalence was higher than that reported in the general adult Brazilian population. Educational level, income level, smoking, condom use, incarceration, illicit drug abuse, the sharing of used needles and syringes without adequate disinfection, homosexual relationships, prostitution, the sexual practices among drug users, and avoidance of con-traceptive methods could contribute to the facilitation of HSV-1 transmission in the Indigenous population. Our results may help develop culturally appropriate intervention programs that eliminate health-access barriers and improve the implementation of public health policies aimed at promoting information re-garding and preventing, treating, and controlling HSV-1 infection in Brazilian Indigenous populations

Palavras-chave

Human alphaherpesvirus 1; Human herpes virus 1; Indigenous; Ethnicity; Epidemiology

Agradecimentos

CAPES,FAPERJ,CNPq,CNPq Grants 440245/2018-4,FUNDECT 041/2017